effect of arsenic on neural tube in mouse embryo and relation to reduced folate carrier (rfc-1)
نویسندگان
چکیده
arsenic is an important environmental toxicant which is usually found in drinking water in inorganic form. the hypothesis tested in this investigation is; arsenic exposure causes neural tube defects (ntds) andthese defects of the central nervous system are more likely related to folate deficiency during fetal life. in this study, sodium arsenate was administered via intraperitoneal route at a rate of 40 mg/kg body weight on the 6th day of gestation to every individual of 20 mated albino mice. on the 8th (e8), 10th (e10), 16th (e16) and 19th (e19) days of the gestation, the pregnant mice in control and experimental groups were sacrificed by cervical dislocation. all embryos belonging to (e16) and (e19) were examined for external morphological neural tube defects. histological staining techniques were haematoxylin and eosin and theimmunofluorescence staining was also implemented. it was observed that, the intraperitoneal injection ofsodium arsenate caused a number of morphological neural tube defects including; open fourth ventricle,exencephally, myelomeningocele and anencephaly. difference in control and experimental specimens wassignificant (p
منابع مشابه
Effect of arsenic on neural tube in mouse embryo and relation to reduced folate carrier (RFC-1)
Arsenic is an important environmental toxicant which is usually found in drinking water in inorganic form. The hypothesis tested in this investigation is; arsenic exposure causes neural tube defects (NTDs) andthese defects of the central nervous system are more likely related to folate deficiency during fetal life. In this study, sodium arsenate was administered via intraperitoneal route at a r...
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15 صفحه اولReduced folate carrier gene is a risk factor for neural tube defects in a Chinese population.
BACKGROUND There is a considerable body of data demonstrating that periconceptional supplementation of folic acid can prevent a significant proportion of neural tube defects (NTDs). At present, the mechanism by which folic acid exerts its beneficial effect remains unknown. Folate transporter genes, including the reduced folate carrier gene (RFC1), have been proposed as NTD risk factors. METHO...
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The reduced folate carrier (RFC), a bidirectional anion transporter, is the major uptake route of reduced folates essential for a spectrum of biochemical reactions and thus cellular proliferation. However, here we show that ectopic overexpression of the RFC, but not of folate receptor alpha, a high affinity unidirectional folate uptake route serving here as a negative control, resulted in an ap...
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عنوان ژورنال:
iranian journal of veterinary researchناشر: shiraz university
ISSN 1728-1997
دوره 13
شماره 3 2012
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